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Almirall and Eloxx Sign an Exclusive Licensing Agreement for Rare Dermatological Pathologies

Almirall has acquired exclusive rights to Eloxx Pharmaceuticals’ ZKN-013, a potentially promising treatment for rare dermatological diseases. Almirall gains global development and commercialization rights, paying Eloxx an initial $3 million and potential additional payments and royalties based on milestones and sales, amounting to $470 million. ZKN-013 is expected to enter phase I development soon.




Almirall buys the exclusive rights to a possible new treatment from Eloxx Pharmaceuticals. The two companies have signed an exclusive license agreement for the ZKN-013 asset for rare diseases, as reported by the biopharmaceutical company to the National Securities Market Commission (Cnmv) this Wednesday.

Almirall, under the agreement, obtains global rights to develop and commercialize ZKN-013 , including its use in orphan dermatological diseases. Specifically, ZKN-013 is a “potentially promising” orally administered drug that allows host cells to produce functional proteins that counteract the root cause of missense mutations in rare and potentially other dermatological diseases.

This drug candidate is expected to enter “phase I development soon in healthy volunteers,” as Almirall has detailed, while explaining that, under the terms of the agreement, Eloxx will receive an initial payment of three million dollars, and additional payments throughout potential development phases , including “regulatory milestones” and sales of up to $470 million, as well as tiered royalties based on any potential future global sales.

Read more about the agreement between Almirall and Eloxx Pharmaceutical and fidn the most important business news of the day with the Born2Invest mobile app.

Almirall closed 2023 with net losses of 38.5 million euros

However, Almirall has stressed that recessive dystrophic epidermolysis bullosa (Ebdr) and junctional epidermolysis bullosa (JEB) are rare skin diseases characterized by defects in the Collagen7 gene, “essential” for the correct formation of the skin structure. and barrier function.

The biopharmaceutical company commented that ZKN-013 has demonstrated “solid preclinical functional activity” in cells from patients with Ebdr or JEB and in APCmin (multiple intestinal neoplasia) mice. “The studies demonstrated that ZKN-013 induces the production of functional, full-length COL7 in cells from patients with Ebdr and JEB with nonsense mutations for this protein,” Almirall said in a statement.

The Spanish pharmaceutical company recorded net losses of 38.5 million euros in 2023 due to impairment charges associated with the book value of the oral acne antibiotic Seysara. This result was offset on the stock market by the announcement of an exclusive licensing agreement with Novo Nordisk to exploit the rights to the monoclonal antibody NN-8828, which blocks the cytokine IL-21.

Based on this agreement, Almirall obtains global rights to develop and commercialize the Danish pharmaceutical company’s compound in certain indications, including immune-mediated inflammatory dermatological diseases.


(Featured image by Kjerstin_Michaela via Pixabay)

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Eva Wesley is an experienced journalist, market trader, and financial executive. Driven by excellence and a passion to connect with people, she takes pride in writing think pieces that help people decide what to do with their investments. A blockchain enthusiast, she also engages in cryptocurrency trading. Her latest travels have also opened her eyes to other exciting markets, such as aerospace, cannabis, healthcare, and telcos.