The Spanish company, Biontaxis, a spin-off of the Institut d’Investigació Germans Trias i Pujol de Badalona (Barcelona) specializing in neurological diseases, has obtained public funding from the Government for a value of €1.1 million.
Biontaxis has obtained funding through the European Recovery and Resilience Mechanism through the Center for Industrial Technological Development (Cdti) for its gene therapy project for Friedrich’s ataxia.
Friedreich’s ataxia is a neurodegenerative disease that is considered a rare disease. Mainly, it affects the ability to develop movements, such as walking and talking. The disease progressively aggravates incapacity and lack of autonomy. There is no cure, in case the cause is known, a defect in a gene that produces a mitochondrial protein called frataxin. The genetic problem produces a deficiency of this protein, which damages the neurons of the spinal cord and the cerebellum.
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Biontaxis wants to develop and validate a gene therapy vector based on a new generation of adeno-associated virus
The company will use the resources to continue financing the development of a drug against Friedrich’s ataxia. The research is led by Antoni Matilla and Ivelisse Sánchez from the neurogenetics research group of the Germans Trias i Pujol Research Institute with the collaboration of neurologists from the neurology department of the Germans Trias Hospital and the Valdecilla de Santander Hospital.
The purpose of the project is to develop and validate a gene therapy vector based on a new generation of adeno-associated virus to be effective as a curative treatment in patients with Friedreich’s ataxia. The program is intended to finance experimental development projects in advanced therapies and personalized medicine in cooperation between companies and research organizations.
The next step for the company is to preclinically validate the drug in large animals to complete the preclinical validation as a phase prior to applying to the regulatory agencies for the corresponding authorization to bring the therapy to the clinical stage.
Friedrich’s ataxia is a rare disease that affects one in 40,000 people
Biointaxis was created in 2018 at the Germans Trias i Pujol Research Institute. Throughout its history, the company has received more than two million euros from the Center for Industrial Technological Development (Cdti), a public business entity whose objective is to promote innovation and technological development in Spanish companies, and from Caixa Capital Risc, CriteriaCaixa’s venture capital manager that invests in innovative companies in their initial and growth stages.
Friedrich’s ataxia is a rare disease that affects one in 40,000 people in the world and that appears between the ages of five and twenty, causing degeneration that ends up sending patients to a wheelchair, among many other problems. of health.
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First published in PlantaDoce, a third-party contributor translated and adapted the article from the original. In case of discrepancy, the original will prevail.
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