It is not normal for biotech start-ups to be bought out by “big pharma.” “We must be able to give them the means for their own organic growth,” wrote Gérard de Pouvourville. If the government wants to establish a thriving French biotech industry they need to be willing to pay the price to support it.
In its 2018 report, the Strategic Council for Health Industries has high ambitions: to make France a home for emerging biotech companies, both French and foreign. At the same time, however, the Social Security Financing Plan 2020 programs a $1.4 billion (€1.3 billion) saving on the price of medicines and medical devices.
Access to the reimbursed market in France is guided above all by the concern to make available to patients products with a proven risk-benefit ratio. These medicines need to be based on rigorous evidence, at a price that is sustainable for the national Health Insurance programmes. But is this rigor compatible with real industry policy, at a time when the pharmaceutical sector is undergoing major changes and is experiencing a third biotech revolution?
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Biotechnology transformed the pharmaceutical sector
Biotechnology, which has transformed the pharmaceutical sector, is at the dawn of a new revolution. Today, breakthrough technologies such as cell-based therapies and different approaches to gene therapy are arriving. Many of these innovations are being developed by a new generation of companies. Established players in the pharmaceutical industry rely on these biotechs to innovate. In its 2018 report, the OECD observed that over the period 2010-2012, big pharma companies held 63% of marketing authorizations but that their in-house research contributed only 30% of the total number of marketing authorizations.
Why would innovative companies decide to sell their technology – or even eventually their company – rather than become the new Sanofi? By choice perhaps, by necessity more certainly. Indeed, organizations deciding on access to reimbursed markets are faced with highly innovative technologies, high unit prices, and significant clinical and economic uncertainties.
An increased commercial risk
In this context, emerging biotechs face an increased commercial risk, that of delayed access or even no access at all. The implications of failure are drastic, as these companies often have no source of revenue. Their sustainability and that of their research pipeline depend on their ability to launch their first products in order to generate the revenues needed to repay their debts but also to invest in further innovation. Although they are at the origin of most of the recent pharmaceutical revolutions, many innovative biotechs are therefore often forced to relinquish their licenses or sign co-development partnerships with big pharma.
The takeover of small businesses by established companies can be considered normal in a competitive world. But it is also a cause for concern. Indeed, the acquisition of companies can lead to a risk of outbidding and excessively high acquisition costs, which can result in high drug prices.
Is it, therefore, inevitable that young biotechs will only be absorbed by a large group? Or can they also hope to grow organically? For a country like France, this is a considerable industrial challenge recognized by the public authorities, in terms of scientific, technological and clinical expertise, but also in terms of job creation and exports. We are entitled to wonder whether it is not strategically and politically more interesting to support investment, competition and the creation of jobs and companies, rather than the outsourcing of risk and the internalization of profits by established companies.
For the government, it is time to finally make a break with twenty years of (lack of) branch policy for the biotech sector. This means inventing a new doctrine of market access and pricing.
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First published in LesEchos, a third-party contributor translated and adapted the article from the original. In case of discrepancy, the original will prevail.
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